Международный центр медицины под руководством профессора И.В. Кривопалова - Москвина
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Apitoxinotherapy in the treatment of Parkinson

Parkinson's disease belongs to a group of illnesses, which are hardly treated by the existing therapeutic methods.

I. To do everything to stop disease development~
2. To get positive dynamics with the help of DOFA-excretion increase and catecholamine (dopamine, adrenaline, noradrenaline );
3. Syndrome therapy;
4. Physical rehabilitation;
5. Psycho-emotional rehabilitation;
6. To change the quality of life.

No doubt, the treatment of Parkinson's disease needs strong and various influence. As a medicament, which can influence just that way, we use apitoxins.

The aims of the bee venom treatment of Parkinson's disease are:
I. To provide necessary dopaminergic activity;
2.To inhibit the degenerative processes in the brain tissue;
3.To normalize motion activity;
4.To correct psycho-emotional state.

The table of main effects of apitoxinotherapy in the treatment of Parkinson's disease by I. V. Krivopalov-Moscvin

Effects Assisting factors and mechanisms of the actived effect
I. Pathogenetic direction ­normalization of the dopamine concentration
  • Bee venom includes necessary doses of dopamine.
  • Stimulation of the biogenic amines , system.
  • Through the system of the regulative peptides.
2. Improvement of the central nervous system neurotrophy
  • Direct and indirect anticoagulative action of the bee venom (particularly, of melittine ).
  • Influence on the thrombocyte activity.
  • Fibrinolytic action of the bee venom.
  • Melittine and cardiopep widen the vascular lumen.
  • Bee venom includes 18 amino acids, which take part in the construction of the nerve fiber.
3. Improvement of the neurological status and motion activity:
a) Muscular rigidity lessens.
b) Tremor decreases.
c) Normalization of the gait.
  • Apamin is able to penetrate through the brain-blood barrier.
  • Improvement of the functional connections between central nervous system and cervical parts of the spinal cord.
  • Suppressive influence of sekapin, tertiapin.
  • Inhibition effect of melittine on the subcortical structures and brain cortex.
  • Reflective stimulation of the biologically active points.
  • Apikinesitherapy.
4. Normalization of the psycho­emotional state
  • Regulation of the mood through the system of endogenous opioids.
  • Indirect effect of sekapin, tertiapin.
5. Nonspecific immunity increases
  • Stress-syndrome of the bee venom introduction.
  • Activation of the regulatory peptides system.
6. Anticholesterol effect
  • The level of cholesterol in the blood decreases.
  • Destruction of the atherosclerotic plaques.

On the whole positive dynamics is always gained

The forms with low muscular tonus were more "sensible" to apitherapy.
Positive dynamics was gained not only in the clinical condition, but in the course of the disease, because apitoxins are able to influence all the structural components of the Parkinson's disease.

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